Bio-Patch Technology
Representative histological section of goat lumbar IVDs repaired with the NovaVia Bio-Patch after discectomy at 6-weeks post-operatively.
(Left) Cross-section illustrating multi-laminate Bio-Patch (green) sealing the defect pathway and in direct contact with native AF.
(Right) Magnified image illustrating IVD tissue and cell infiltration (blue) within and around the Bio-Patch layers (green).
Bio-Patch was deployed and secured to the IVD in less than 5-minutes using the integrated Bio-Annular Repair System (BARS).
Collagen-based AF-mimetic patch designed to cover annular defects after lumbar discectomy.
Multilaminate, angle-ply scaffold derived from acellular pericardium and a polymer core.
Overlaid sheets of pericardium sutured together yielding collagen fiber preferred direction oriented at ±30 degrees to the horizontal axis of the spine in alternating layers similar to the native AF.
Patent(s): EP3347062B1 / US10675381B2
Bio-Patch Structure and Function Mimics the
Native AF
Bio-Patch Provides Biological Cues to Guide Cells
Bio-Patch Seals AF Defects, Supports Host Cell Infiltration and Integration with AF Tissue In Vivo
Microscopically confirmed collagen ply-angle microarchitecture.1
Uniaxial and biaxial tensile static and fatigue properties comparable to native AF.1,2
Resists radially directed multi-axial burst and impact loads expected clinically.2,3
Aids in restoring ex vivo functional spinal unit (FSU) tensile kinematic parameters.2,3
Prevents herniation of biologic NP replacements under supra-physiologic stresses in ex vivo testing.2
Click Below To Learn More About NovaVia's Bio-Annular Repair System
Bio-Patch Peer-Reviewed Publications
1 McGuire, R., et al. The fabrication and characterization of a multi-laminate, angle-ply collagen patch for annulus fibrosus repair.” Journal of Tissue Engineering and Regenerative Medicine. Dec (2017) 11(12):3488-3493.
2 Borem, R., et al. Angle-ply biomaterial scaffold for annulus fibrosus repair replicates native tissue mechanical properties, restores spinal kinematics, and supports cell viability.” Acta Biomaterialia. Aug (2017). 58, 254-268.
3 Borem, R., et al. Multi-laminate annulus fibrosus repair scaffold with an interlamellar matrix enhances impact resistance, prevents herniation and assists in restoring spinal kinematics.” Journal of the Mechanical Behavior of Biomedical Materials. Apr (2019). 95:41-52.
4 Borem, R., et al. Angle-ply scaffold supports annulus fibrosus matrix expression and remodeling by mesenchymal stromal and annulus fibrosus cells.” Journal of Biomedical Materials Research – Part B. May. (2022). 110(5):1056-1068.
Supports AF cell viability, phenotype and matrix remodeling.4
Promotes mesenchymal stem cell differentiation towards and AF cell-like phenotype.4
Guides cell alignment and extracellular matrix production in the collagen fiber preferred direction.4